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KMID : 1011720180110020172
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International Journal of Thyroidology
2018 Volume.11 No. 2 p.172 ~ p.175
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A Case of Aggravation of Thyroid Goiter after Treatment with PD-1 Inhibitor for Breast Cancer in Patients with Underlying Hashimoto's Thyroiditis
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Kim Ha-Na
Kim Min-Joo
Song Young-Shin
Cho Sun-Wook
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Abstract
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Anti-programmed cell death-1 (PD-1) humanized monoclonal antibody inhibits PD-1 activity by binding to the PD-1 receptor on T-cells and blocking PD-1 ligands and induces immune tolerance of cancer cells. It has been widely used for various kinds of cancer treatment. However, many immune-related adverse events (irAEs) have been reported because it modulates our immune system. In this case study, we reported a case of 42-year-old woman with Hashimoto's thyroiditis who showed rapid aggravation of thyroid goiter and acute hyperventilation syndrome after treatment with PD-1 inhibitor as a neoadjuvant chemotherapy for breast cancer.
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KEYWORD
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PD-1 inhibitor, Immune-related adverse events (irAEs), Hashimoto's thyroiditis, Goiter
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